Endocrine Abstracts

A rare and aggressive form of thyroid malignancy, medullary thyroid carcinoma (MTC) is virtually incurable except by complete surgical resection. Due to its insidious onset and extensive spread at diagnosis, its prognosis is often poor.Aim: To evaluate treatment outcome and prognosis in patients diagnosed with MTC admitted to our department between 2004 and 2013.Patients and methods: We identified 21 patients (eight men and 13 wome...

A 42-years woman presented with hypothyroidism, a large, firm, irregular goiter, severe cervical and preauricular pain, 2 weeks after an episode of respiratory infection. Laboratory findings certified subacute thyroiditis and autoimmune hypothyrodism: TSH>50 μUI/ml, FT4=6.5 pmol/l, ATPO>1000 U/ml, ATGL>1000 U/ml, ESR=115 mm/1 h. Thyroid ultrasound showed hypoechogenic pattern with a nodule on the right lobe and low Doppler signal. Fine needle aspira...

Introduction: The coexistence of hyperthyroidism and thyroid cancer is rare (below 2% of cases with hyperthyroidism). If this association predisposes to larger, multifocal or more aggressive cancer (especially in Graves’ disease) is a matter of debate. We describe the clinical and hystopathological aspects and evolution in two patients with hyperthyroidism and thyroid cancer.Patient 1, a 42-year-old woman, was diagnosed in 2008 with Graves’ dis...

Adrenal cortical carcinoma is a rare disease with an incidence of 1–2/million per year. Diagnosis is related to autonomy of adrenal steroid synthesis, tumour size above 6 cm, local invasion and tendency to recurrence. Treatment consists in adrenal surgery, non-specific chemotherapy and radiotherapy, and, more specific-Mitotane (Lysodren).Pathology diagnosis is based on capsular and vascular invasion, histological changes suggestive for malignancy an...

Introduction: Occurring sporadically or as part of a familial syndrome, medullary thyroid carcinoma (MTC) is insidious in onset, aggressive in behavior and invariably a challenge to the clinician and surgeon.Objective: To define the relationship between biochemical parameters, disease progression, and treatment outcome in patients with MTC.Patient and methods: We studied 35 patients (11 men, 24 women) aged 50.9±14.8 years, adm...

The multiple endocrine neoplasia syndrome type 2A (MEN 2A) is the consequence of a heritable mutation in the RET proto-oncogene, leading to a very high predisposition to develop medullary thyroid carcinoma (MTC), pheochromocytoma and primary parathyroid hyperplasia. Screening of ‘at-risk’ family members and prophylactic thyroidectomy is recommended – but not always easily accomplished.Our proband was diagnosed with MTC in 1977 (at age 21),...

Background: One of the major complications developed by patients with end stage renal disease (ESRD) is secondary hyperparathyroidism (SHPT), due to hypocalcaemia, hyperphosphatemia and 1,25(OH)2D deficiency with parathyroid hyperplasia and high PTH levels as earliest changes, which may require parathyroidectomy (PTX).Study design and objectives: This study aimed to evaluate the indications, the particularities and outcomes post-PTX of patient...

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor derived from the thyroid C cells producing calcitonin, ac-counts for 0.6% of all thyroid cancers. It occurs either sporadically or in a hereditary form (RET mutation). MTC can be cured only by complete resection of the thyroid tumor and any loco-regional metastases. Calcitonin (CT) measurement is crucial to the early diagnosis and the follow-up of MTC. If the evaluation of stimulated CT levels is required, a prov...

Introduction: The metabolic complications in adrenal tumors, regardless secretor or not, are a common finding, thus representing a supplementary warning in these patients related to the non-endocrine therapy as anti-hypertensives, or hypolipemiants drugs, etc.Aim: We analyze the frequency of metabolic complications in primitive adrenal tumors.Materials and methods: This is a retrospective study in patients diagnosed with adrenal tu...

Introduction: Incidentaloma is a randomly discovered tumor with no apparent secretor activity. The term is mainly used for hypophysis and adrenals. There are relatively few situations where a patient has more than one such mass.Aim: To present the case of a patient with three tumors: a pituitary mass and bilateral adrenal masses, with clinical manifestations of Cushing’s syndrome.Case report: A 37-year-old female patient who h...